ABSTRACT
We present a description of the Central Sensitivity Syndrome (CSS) and some of its main components such as Multiple Chemical Sensitivity Syndrome, Chronic Fatigue Syndrome and Fibromyalgia. We review the changes in pain perception, describing the physiology and pathophysiology of the painful experience from the medulla horn to the CNS. We explain the theory of central sensitization as the basis to the syndrome. We refer to the differences between fibromyalgia and depressive disorders, is spite of their frequent presentation in comorbidity. We state the main clinical and neurobiological differences. We point out the main psychoneuroimmunoendocrinologic differences such as adrenal activity (hypoactivity vs. hyperactivity, DST hypersuppressive response vs. DST non suppression, hypersensitivity of central glucocorticoid receptors vs. desensitization of these, among others), thyroid (probable reverse T3 vs. flat stimuli TSH response curve) and growth hormone secretion (probable increase vs. disruption of normal circadian rhythm) that makes CSS resemble PTSD. We describe differential changes in sleep patterns (alpha-delta intrusion vs. altered sleep time, REM latency, and stage 3/4) and immunological disturbances almost opposite in each pathological entity. We finally argue which medical specialty should treat these complex syndromes.
Subject(s)
Fibromyalgia/complications , Multiple Chemical Sensitivity/complications , Fatigue Syndrome, Chronic/complications , Depressive Disorder/complications , Humans , SyndromeSubject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Tuberculosis, Pulmonary/complications , Bronchiectasis/complications , Bronchiectasis/epidemiology , Multiple Chemical Sensitivity/complications , Socioeconomic Factors , Comorbidity , Serial Cross-Sectional Studies , Epidemiology, Descriptive , Retrospective Studies , Cough , DyspneaABSTRACT
Presentamos un niño de 18 meses de edad, con pelo verde, debido a su exposición a polvillo o nube con trazas de cobre, desde una industria hogareña. Revisamos las posibles causas de pelo verde, un problema dermatológico muy inusual
Subject(s)
Humans , Male , Infant , Copper/adverse effects , Hair Color/drug effects , Copper/analysis , Copper/toxicity , Dose-Response Relationship, Drug , Occupational Exposure/adverse effects , Multiple Chemical Sensitivity/complications , Multiple Chemical Sensitivity/diagnosisABSTRACT
Se presenta un estudio multicéntrico efectuado en nueve hospitales de Caracas entre julio de 1995 y marzo de 1996. En este trabajo se comparó la sensibilidad a cefalosporinas de tercera (cefotaxima, ceftazidima, ceftriaxona y cefoperazona) y cuarta generación (cefepime) en diferentes cepas de bacterias mantenidas in-vitro. Para tal efecto se obtuvieron un total de 1 717 microorganismos, de los cuales 1 369 (80 por ciento) eran Gram negativos y 342 (20 por ciento) Gram positivos. En los Gram negativos se encontró resistencia considerable a cefalosporinas de tercera generación en algunos centros de estudio, no así a cefepime. Las bacterias Gram positivas, Staphylococcus aureus y Streptococcus pneumoniae, fueron más sensibles a cefepine que a todas las cefalosporinas de tercera generación. Se concluye que las bacterias tienen a ser resistentes a cefalosporinas de tercera generación. Por tal razón, cefepime representa una alternativa importante en el tratamiento de infecciones causadas por germenes Gram negativos multiresistentes y mixtas por bacterias tanto Gram positivas como Gram negativos.